HPE systems powered by AMD Unlock potential from edge to exascale with HPE and AMD
With over 50 years of experience delivering industry-leading servers, storage, and supercomputers, HPE and AMD have the technology, services, and support to help you reach your goals.
Accelerate demanding compute and production AI with HPE and AMD
Meet the HPE ProLiant DL525 Gen13 Server and HPE ProLiant Compute DL585a Gen13. Powered by AMD EPYC 9006 Series processors, these purpose-built platforms support performance-intensive computing, AI inference, modeling, simulation, analytics and production AI.
HPE and AMD joint solutions
- Edge Compute
- Core Compute
- HPC & AI Systems
- HPE Alletra Storage MP B10000
- HPE Cray Supercomputing
Power business everywhere with compute optimized for the edge
Elevate your business operations and enhance productivity with compute solutions designed for your unique edge environment. Transform edge data into actionable insights rapidly with powerful, AI-ready servers.
Compute engineered for your hybrid world
Unleash breakthrough performance with HPE ProLiant and AMD EPYC—secure, efficient, and optimized to power your workloads, from Virtualization to AI, with tailored, future-ready server solutions.
Accelerate AI training with game-changing, purpose-built architecture
HPE HPC & AI Systems, powered by AMD EPYC CPUs, AMD Instinct GPUs, and a portfolio of advanced software and services, are all engineered for the most complex AI training workloads.
Unified block and file storage
The exascale era has arrived—ushered in by HPE and AMD
HPE and AMD have delivered many of the world's fastest and most efficient supercomputers, which accelerate scientific discovery around the globe.
Compare HPE systems powered by AMD
- Edge Compute
- Core Compute
- HPC & AI Systems
- Alletra Storage MP
- HPE Cray Supercomputing
| Product | Workloads | Rack units | Processor | Max memory | Max storage | Accelerator | Resources |
|---|---|---|---|---|---|---|---|
| HPE ProLiant DL145 Gen11 | Support critical business applications, virtualization, and AI workloads at the edge | 2U | AMD EPYC 4th Gen | 768 GB | 92 TB | NVIDIA L4 |
| Product | Workloads | Rack units | Processor | Max memory | Max storage | Accelerator | Resources |
|---|---|---|---|---|---|---|---|
| HPE ProLiant DL385 Gen11 | AI/ML, HPE Telco, Database Analytics | 2U (air ) | AMD EPYC 5th or 4th Gen | Up to 6TB DDR5 6400 MT/s total, CXL 1.1 supported | NVIDIA RTX PRO 6000, L40S, L40, L4, H100, H200, A16 | ||
| HPE ProLiant DL365 Gen11 | VDI, EDA/CAD; General Purpose Virtualization | 1U (air or liquid) | AMD EPYC 5th or 4th Gen | Up to 6TB DDR5 6400 MT/s total, CXL 1.1 supported | Up to 10 SFF 20EDSFF | NVIDIA A16, NVIDIA L4 | |
| HPE ProLiant DL345 Gen11 | Software defined storage; Video transcoding | 2U (air) | AMD EPYC 5th or 4th Gen | Up to 3TB, DDR5 up to 6400 MT/s, CXL 1.1 supported | Up to 20LFF, 34SFF, 36EDSFF | NVIDIA A16, NVIDIA L4 | |
| HPE ProLiant DL325 Gen11 | Software defined compute; CDN; low-end VDI | 1U (air) | AMD EPYC 5th or 4th Gen | Up to 3TB, DDR5 up to 6400 MT/s | Up to 4LFF, 10SFF, 20EDSFF | NVIDIA A2, NVIDIA L4 | |
| HPE ProLiant Compute DL345 Gen12 | Virtualization, SDS, Data Management | 2U (air, CLLC, or liquid) | AMD EPYC 5th Gen | Up to 6TB, DDR5 up to 5200 MT/s | Up to 12LFF, 26SFF, 36EDSFF | NVIDIA L4 | |
| HPE ProLiant Compute DL325 Gen12 | Hybrid Cloud, Container, Virtualization | 1U (air or liquid) | AMD EPYC 5th Gen | Up to 6TB, DDR5 up to 5200 MT/s | Up to 4LFF, 10SFF, 20EDSFF | NVIDIA L4 | |
| HPE ProLiant DL525 Gen13 | AI inferencing, modeling, simulation, EDA, data-intensive analytics and high-performance computing | 1U rack optimized | 1 x AMD EPYC 9006 SP7 Server CPU, up to 256 cores | Up to 4 TB DDR5 at up to 8000 MT/s, or 2 TB MRDIMM at up to 12,800 MT/s | Up to 20 EDSFF E3.S 1T SSD; up to 1 M.2 2280 SSD | Up to 2 Double Wide or 4 Single Wide FHFL at the front; up to 3 Single Wide HHHL at the rear |
| Product | Workloads | Rack units | Processor | Max memory | Max storage | Accelerator | Resources |
|---|---|---|---|---|---|---|---|
| HPE Cray XD225v | High performance compute | 1U (air or liquid) | AMD EPYC 5th or 4th Gen | 6400 MT/s | 2NVMe SSDs, 1 M.2 NVMe | N/A | |
| HPE Cray XD295v | High performance compute | 2U (air or liquid) | AMD EPYC 5th or 4th Gen | 6400 MT/s | 4NVMe SSDs, 1 M.2 NVMe | AMD Instinct MI210 or NVIDIA H100, L40s | |
| HPE ProLiant Compute XD685 | Large-scale AI model training and tuning | 5U (liquid) | AMD EPYC 5th Gen | 6.0 TB | 184.4 TB | AMD Instinct MI355X or NVIDIA H200 or B200 | |
| HPE ProLiant Compute DL585a Gen13 | LLM inference, agentic AI, retrieval-augmented generation (RAG), fine-tuning, computer vision and multimodal AI | 10U rack | AMD EPYC 9006 Series processors, up to 512 cores total | Up to 8 TB DDR5 at up to 8000 MT/s, or 4 TB MRDIMM at up to 12,800 MT/s | Up to 16 EDSFF drives | Up to 8 Double Wide or 16 Single Wide GPUs; NVIDIA RTX PRO 6000 Blackwell Server Edition, NVIDIA H200 NVL, AMD Instinct MI350P |
| Product | Workloads | Rack units | Processor | Max memory | Max storage | Accelerator | Resources |
|---|---|---|---|---|---|---|---|
| HPE Alletra Storage MP B10120 | General purpose mission-critical block storage | 2U | AMD EPYC 8 core | 256GB/node | Supports up to 737TB raw capacity | N/A | |
| HPE Alletra Storage MP B10130 | General purpose mission-critical workloads | 2U | AMD EPYC 16 core | 256GB/node | Supports up to 2.2PB raw capacity | N/A | |
| HPE Alletra Storage MP B10140 | General purpose mission-critical workloads | 2U | AMD EPYC 32 core | 512GB/node | Supports up to 2.2PB raw capacity | N/A | |
| HPE Alletra Storage MP B10230 | Enterprise mission-critical workloads | 4U+ | AMD EPYC 16 core | 256GB/node | Supports up to 5.9PB raw capacity | N/A | |
| HPE Alletra Storage MP B10240 | Enterprise mission-critical workloads | 4U+ | AMD EPYC 32 core | 512GB/node | Supports up to 5.9PB raw capacity | N/A | |
| HPE Alletra Storage MP X10000 | Data-intensive workloads including Retrieval-Augmented Generation (RAG), large language models (LLMs), active data lakes, modern data protection with rapid restore from backup datasets | 8U+ | AMD EPYC 64 core | 512GB/node | Supports up to 12PB raw capacity per cluster | N/A |
| Product | Workloads | Rack units | Processor | Max memory | Max storage | Accelerator | Resources |
|---|---|---|---|---|---|---|---|
| HPE Cray Supercomputing Storage Systems E2000 | Highest performance file storage for supercomputers and large compute clusters running modeling and simulation, AI, and high-performance data analytics | 2U | AMD EPYC 5th Gen | N/A | |||
| Cray ClusterStor E1000 Storage Systems | High performance file storage for supercomputers and large compute clusters running modeling and simulation, AI, and high-performance data analytics | 2U | AMD EPYC 4th Gen | N/A | |||
| HPE Cray Storage Systems C500 | High performance file storage for compute clusters running modeling and simulation, AI, and high-performance data analytics | 2U | AMD EPYC 4th Gen | N/A | |||
| HPE Cray SC EX4252 Compute Blade | CPU-based compute blade with 8 CPUs targeting modeling & simulation workloads | 1U | AMD EPYC 5th or 4th Gen | ||||
| HPE Cray SC EX4252 Gen2 Compute Blade | CPU-based compute blade with 8 CPUs up to 500W and 192 cores targeting modeling & simulation workloads | 1U | AMD EPYC 5th or 4th Gen | ||||
| HPE Cray SC EX255a Accelerator Blade | APU-based accelerator blade with 8 APUs targeting converged AI and HPC workloads | 1U | AMD Instinct MI300A APUs | AMD Instinct MI300A APUs |
