HPE ProLiant Compute DL380 Gen12

Designed for enterprise and hybrid cloud workloads, the HPE ProLiant Compute DL380 Gen12 is a scalable 2U 2P platform powered by Intel® Xeon® 6 processors with up to 144 cores and high memory density.

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HPE ProLiant Compute DL380 Gen12.
HPE ProLiant Compute DL380 Gen12.

HPE ProLiant Compute DL380 Gen12

Meet the HPE ProLiant Compute DL380 Gen12—a powerhouse 2U, dual-socket server built to deliver blazing-fast compute performance, massive memory scalability, and lightning-quick data transfer rates. Fueled by the latest Intel® Xeon® 6 processors with up to 144 cores, support for up to a staggering 8 TB of memory, and room for 36 EDSFF E3.S drives, this server is engineered to handle heavy enterprise applications with ease. Designed to future-proof your IT infrastructure, the HPE ProLiant Compute DL380 Gen12 combines advanced security features, performance-optimized architecture, and intelligent, AI-driven automation—making it the ultimate hybrid cloud platform for businesses that demand more from their servers.

What's new

  • Up to three double-wide (DW) or eight single-wide (SW) GPUs.
  • Intel® Xeon® 6 processors that support up to 144 cores, up to 8 TB of DDR5 memory at speeds up to 6400 MT/s, and up to 2x average higher performance for general compute versus previous generations.
  • Optional front accessible boot device for quicker access.
  • Choice of two cooling options—air cooling or direct liquid cooling (DLC) for performance and energy efficiency to support sustainability initiatives.
  • Up to 36 EDSFF E3.S NVMe drives.

Product solutions

Unleash accelerated computing with HPE ProLiant Compute and NVIDIA GPUs

Liquid cooling solutions from HPE

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Servers & Systems: The Right Compute

HPE ProLiant Compute savings estimator

Technical specifications

  • Top workloads

    VDI, Virtualization, Containers, Data Management


  • Form factory

    2U rack


  • Cooling

    Air-Cooled, Direct Liquid Cooling (DLC)


  • Processor

    2P Intel® Xeon 6 processor


  • GPU

    Up to 8 Single-Wide NVIDIA L4 or RTX A1000 or 3 Double-Wide NVIDIA L40S, H100 NVL or RTX PRO 6000 Blackwell Server Edition GPUs


  • Max memory

    Up to 8TB DDR5


  • Storage

    LFF, SFF, EDSFF drives


  • Management

    HPE iLO 7, HPE Compute Ops Management


Resources

HPE Compute Security

Safeguard against digital and physical threats with next-level security.

HPE ProLiant Compute Solutions

Optimize performance and efficiency in the data center and at the edge, to power tailored workloads from VDI to AI.

HPE ProLiant Compute AI Solutions

Unlock more value from your data and accelerate AI outcomes that deliver insights and innovation.

HPE Tech Care Service for HPE ProLiant Compute

Gain expedited access to trusted experts with deep, product-specific knowledge to get the answers you need, fast!

Financing and IT Lifecycle Services

Remove budget barriers, get the latest tech and accelerate innovation with tailored financing and IT lifecycle services.

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HPE ProLiant Compute Servers

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HPE Integrated Lights-Out (iLO)

Securely configure, monitor, and update your HPE ProLiant servers with industry-leading Silicon Root of Trust.

HPE Compute Ops Management

Seamlessly monitor, manage, and gain visibility of your distributed compute environment with a cloud-native solution.

HPE Services for Compute

Benefit from HPE experts and world-class services professionals to help exceed your business expectations.

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